thought to work by affecting the levels of two chemicals in the brain -- serotonin and norepinephrine. tell your doctor right away if your depression worsens or you have unusual changes in mood, behavior, or thoughts of suicide. anti-depressants can increase suicidal thoughts and behaviors in children, teens, and young adults. pristiq is not approved for children under 18. do not take pristiq with maois. taking pristiq with nset pain relievers, aspirin, or blood thinners may increase bleeding risk. tell your doctor about all your medications, including those for migraine, to avoid a potentially life threatening condition. pristiq may cause or worsen high blood pressure, high cholesterol, or glaucoma. tell your doctor if you have heart disease or before you reduce or stop taking pristiq. side-effects may include nausea, dizziness and sweating. for me, pristiq is a key in helping me treat my depression.